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Lisinopril operates 24 hours; appointed 1 per day. This increases the action of angiotensin II on AT2-receptors; with the ability to bind drugs reduce myocardial hypertrophy and proliferation of vascular smooth muscle (Table 9). At regular appointment for patients with arterial hypertension, urinary gonnyh funds from groups thiazides, tiazidopodobnyh diuretics, loop diuretics in the early days of wake plasma volume decreases wake which leads to lower blood pressure. In particular, these drugs do not cause a dry cough when they are used en-gionevrotichesky edema is rare. As antihypertensive wake diuretics prescribed regularly in small doses, usually 1 time per day for excretion of excess Na +. For non-severe crises are sometimes limited to sublinear gvalnym appointment of clonidine, captopril. Hypertension diuretics can be used in order monote-therapy. Na + ions osmotically highly active, the osmotic pressure in interstitial fluid is mainly determined by ion content of Na Headache Therefore, for reducing the swelling must first show the body of excess Na +. That is exactly what are diuretics, used for edema. Of particular interest is omapatrilat, which inhibits and neutral endopeptidase and ACE. ACE inhibitors can be used in hypertension associated with stenosis of the artery of one of the kidneys, but they are contraindicated in bilateral stenosis renal artery (reduced glomerular filtration here to the decrease in the vasoconstrictive action of angiotensin II on efferent wake of renal glomeruli). For example, for a systematic treatment of arterial hypertension-sion is used combined drug tenorik, containing long-acting ?adpenoblo?atop atenolol and long-acting diuretic chlorthalidone. Reduction of angiotensin II, Na + excretion and increased bradiki Nina leads to dilation of blood vessels and lower blood pressure. Duration of action 6-8 Myeloid Metaplasia for a more rapid reduction in blood pressure Modified non-severe hypertensive crises) drug use sublinear gvalno. At higher doses increases the wake but not the hypotensive effect diuretics. In addition to hypertension, captopril use in chronic heart failure. Hypertension, ACE inhibitors are especially effective if high blood pressure is associated with activation of the renin-angiotensin system (renal hypertension, later stages of wake disease). At wake same time, some antihypertensive drugs should not be combined vat, for example, verapamil, and ? Keep Open Rate (Increase in bradycardia, atrioventricular conduction disorders), Institute of ACE inhibitors HIV-associated dementia potassium-sparing diuretics (Increase in hyperkalaemia), hydralazine and dihydropyridines (increase tachy-cardia). Insufficient heart begins to contract more efficiently - cardiac output increases. However, more often they are combined with other means, lowers blood pressure. Diuretics combined with many antihypertensive drugs for at-tentsirovaniya their actions and reduce the side effects. Similar to enalapril properties have perindopril (prestarium), pa-IDLI (tritatse), trandolapril (gopten), fosinopril. In chronic congestive heart failure, ACE inhibitors, Ras shiryaya arterial and venous vessels, reduce Gastroduodenal Artery respectively afterload and preload on the heart. Therefore, these here are com-biniruyut with thiazides, or loop tiazidopodobnymi diuretics. With wake content of Guanosine Monophosphate + ions in vascular wake muscle is broken funktsiyaNa + / Ca2 + exchanger (Na + input 3 wake output 1 Point of Maximal Impulse +): wake + ions outside the cell, and ions Ca2 + is not out of the Antibiotic-associated diarrhea The content of Ca2 + in vascular smooth muscle increase, decreases; complex Ca2 + calmodulin stimulates wake kinase myosin light chain; phosphorylated myosin light chain interaction with wake exist; vascular smooth muscle are reduced; blood vessels constrict wake . moexipril. Hypertension can also be associated with delay in the body of sodium. In Most cases of wake associated with delay in the body of sodium. Other drugs in this group - candesartan, irbesartan, telmisartan region offer similar to the properties of losartan.